The Shinozaki Laboratory studies the molecular influence of environmental factors such as trauma, stress, and inflammation on individual susceptibility to psychiatric conditions including major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and delirium using epigenetic/genetic approaches as well as a medical engineering approach through device development and machine learning.

The main focus of the Shinozaki Lab has been to examine epigenetic changes resulting from exposure to stress such as trauma or inflammation to aid in the search of biomarkers of stress exposure and risk for MDD, PTSD, and delirium. Dr. Shinozaki, in collaboration with many colleagues across different fields, successfully developed several ongoing projects in epigenetics/genetics- one in collaboration with neurosurgeons to study DNAm correlation between brain tissue and peripheral tissues, which is supported by NIH R01 funding. 

From the angle of neuroinflammation, we are investigating the role of epigenetics in inflammatory processes in delirium and aging. In addition to epigenetics investigation, we are developing a novel electroencephalography (EEG) device to screen delirium among elderly patients in the hospital.

Recent Updates

June 27, 2021

Our paper, "A thumb-size bispectral EEG (BSEEG) device and standard deviation filtering can capture delirium severity and predict mortality", was accepted by the British Journal of Psychiatry. 

Our visiting scholar, Takehiko Yamanashi, and medical student assistant, Kaitlyn Crutchley, are co-first authors. Congratulations, Kaitlyn and Take!

June 22, 2021

Our paper, "Mortality among patients with sepsis associated with a bispectral electroencephalography (BSEEG) score", was accepted by Scientific Reports!

Our visiting scholar, Take Yamanashi, and undergraduate assistant, Pedro Marra, are co-first authors. Congratulations, Pedro and Take!

June 1, 2021

Shinozaki Lab at Stanford opened. We are looking forward to the new adventure!

May 31, 2021

After successful 8 years at the University of Iowa, Shinozaki lab at Iowa closed.

PI, Gen Shinozaki, MD, thanks the many talented individuals involved, including undergards, med students, residents, faculty collaborators, and more, whose own careers will be for sure filled with great successes in years to come.

May 24, 2021

Our visiting scholar, Dr. Takehiko Yamanashi's paper, "DNA methylation in the TNF-alpha gene decreases along with aging among delirium inpatients", was accepted by the Neurobiology of Aging. 

Congratulations, Take!